drug. It more applys to any drug discovery program employing bio technology. The big molecule drug has its' drwaback too. Because it can not get into cell. and 70% possible drug targets are inside cell. Of course, the advantage for big molecule is much less toxicity. Generic big molecule drug must go through whole clinical study due to its' nature. Regarding integrate CRO, there is still a long way to go. Currently, molecule synthesis, basic PKDM have some solid progress.